Ontology highlight
ABSTRACT:
SUBMITTER: Kao MP
PROVIDER: S-EPMC3137586 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Kao Michelle P MP Ang Donald S DS Gandy Stephen J SJ Nadir M Adnan MA Houston J Graeme JG Lang Chim C CC Struthers Allan D AD
Journal of the American Society of Nephrology : JASN 20110630 7
Allopurinol ameliorates endothelial dysfunction and arterial stiffness among patients without chronic kidney disease (CKD), but it is unknown if it has similar effects among patients with CKD. Furthermore, because arterial stiffness increases left ventricular afterload, any allopurinol-induced improvement in arterial compliance might also regress left ventricular hypertrophy (LVH). We conducted a randomized, double-blind, placebo-controlled, parallel-group study in patients with stage 3 CKD and ...[more]