Ontology highlight
ABSTRACT:
SUBMITTER: Ludwig T
PROVIDER: S-EPMC313794 | biostudies-literature | 2001 May
REPOSITORIES: biostudies-literature
Genes & development 20010501 10
We generated mouse mutants carrying in the Brca1 locus a modification (Brca1(tr)) that eliminates the C-terminal half of the protein product and obtained results indicating that, depending on genetic background, the missing BRCT and/or other domains are dispensable for survival, but essential for tumor suppression. Most of the apparently hypomorphic Brca1(tr/tr) mutants developed various tumors. Lymphomas were detected at all ages, whereas sarcomas and carcinomas, including breast cancer, appear ...[more]