Effect of Steric Constraint at the ?-Backbone Position on the Conformations and Hybridization Properties of PNAs.
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ABSTRACT:
SUBMITTER: Crawford MJ
PROVIDER: S-EPMC3138043 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
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Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs.
Crawford Matthew J MJ Rapireddy Srinivas S Bahal Raman R Sacui Iulia I Ly Danith H DH
Journal of nucleic acids 20110525
Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains. The effects of these side-chains on the conformations and hybridization properties of PNAs were determined using a combination of CD and UV-Vis spectroscopic techniques. Our results show that the γ-position can accommodate varying degrees of sterically hindered side-chains, reaffirming the bimodal ...[more]
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