Ontology highlight
ABSTRACT:
SUBMITTER: Mirabello L
PROVIDER: S-EPMC3138419 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Mirabello Lisa L Yu Kai K Berndt Sonja I SI Burdett Laurie L Wang Zhaoming Z Chowdhury Salma S Teshome Kedest K Uzoka Arinze A Hutchinson Amy A Grotmol Tom T Douglass Chester C Hayes Richard B RB Hoover Robert N RN Savage Sharon A SA
BMC cancer 20110529
<h4>Background</h4>Osteosarcoma (OS) is a bone malignancy which occurs primarily in adolescents. Since it occurs during a period of rapid growth, genes important in bone formation and growth are plausible modifiers of risk. Genes involved in DNA repair and ribosomal function may contribute to OS pathogenesis, because they maintain the integrity of critical cellular processes. We evaluated these hypotheses in an OS association study of genes from growth/hormone, bone formation, DNA repair, and ri ...[more]