Ontology highlight
ABSTRACT:
SUBMITTER: Stover JS
PROVIDER: S-EPMC3138521 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Stover James S JS Rizzo Carmelo J CJ
Chemical research in toxicology 20071004 12
2-amino-3-methylimidazo[4,5-f]quinoline (IQ) is a highly mutagenic heterocyclic amine formed in all cooked meats. IQ has been found to be a potent inducer of frameshift mutations in bacteria and carcinogenic in laboratory animals. Upon metabolic activation, IQ forms covalent adducts at the C8- and N2-positions of deoxyguanosine with a relative ratio of up to approximately 4:1. We have previously incorporated the major dGuo-C8-IQ adduct into oligonucleotides through the corresponding phosphoramid ...[more]