Ontology highlight
ABSTRACT:
SUBMITTER: Keating AK
PROVIDER: S-EPMC3138539 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Keating Amy K AK Kim Grace K GK Jones Ashley E AE Donson Andrew M AM Ware Kathryn K Mulcahy Jean M JM Salzberg Dana B DB Foreman Nicholas K NK Liang Xiayuan X Thorburn Andrew A Graham Douglas K DK
Molecular cancer therapeutics 20100427 5
Astrocytomas account for the majority of malignant brain tumors diagnosed in both adult and pediatric patients. The therapies available to treat these neoplasms are limited, and the prognosis associated with high-grade lesions is extremely poor. Mer (MerTK) and Axl receptor tyrosine kinases (RTK) are expressed at abnormally high levels in a variety of malignancies, and these receptors are known to activate strong antiapoptotic signaling pathways that promote oncogenesis. In this study, we found ...[more]