Ontology highlight
ABSTRACT:
SUBMITTER: Yang M
PROVIDER: S-EPMC3138634 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110523 18
<h4>Purpose</h4>Androgen deprivation therapy (ADT), an important treatment for advanced prostate cancer, is highly variable in its effectiveness. We hypothesized that genetic variants of androgen transporter genes, SLCO2B1 and SLCO1B3, may determine time to progression on ADT.<h4>Patients and methods</h4>A cohort of 538 patients with prostate cancer treated with ADT was genotyped for SLCO2B1 and SLCO1B3 single nucleotide polymorphisms (SNP). The biologic function of a SLCO2B1 coding SNP in trans ...[more]