Ontology highlight
ABSTRACT:
SUBMITTER: Namjoshi OA
PROVIDER: S-EPMC3138730 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Namjoshi Ojas A OA Gryboski Angelica A Fonseca German O GO Van Linn Michael L ML Wang Zhi-jian ZJ Deschamps Jeffrey R JR Cook James M JM
The Journal of organic chemistry 20110504 11
To gain access to 3-propoxy-β-carboline hydrochloride (3-PBC·HCl) (1·HCl) and β-carboline-3-carboxylate-tert-butyl ester (βCCt) (2), potential clinical agents active against alcohol self-administration, a two-step route was developed. This process involves a palladium-catalyzed Buchwald-Hartwig coupling and an intramolecular Heck reaction. This two-step route provides rapid access to multigram quantities of 3-PBC (1) and βCCt (2), as well as analogues for studies of alcohol self-administration. ...[more]