Ontology highlight
ABSTRACT:
SUBMITTER: de Groot JF
PROVIDER: S-EPMC3139373 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
de Groot John F JF Lamborn Kathleen R KR Chang Susan M SM Gilbert Mark R MR Cloughesy Timothy F TF Aldape Kenneth K Yao Jun J Jackson Edward F EF Lieberman Frank F Robins H Ian HI Mehta Minesh P MP Lassman Andrew B AB Deangelis Lisa M LM Yung W K Alfred WK Chen Alice A Prados Michael D MD Wen Patrick Y PY
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110523 19
<h4>Purpose</h4>Antivascular endothelial growth factor (anti-VEGF) therapy is a promising treatment approach for patients with recurrent glioblastoma. This single-arm phase II study evaluated the efficacy of aflibercept (VEGF Trap), a recombinantly produced fusion protein that scavenges both VEGF and placental growth factor in patients with recurrent malignant glioma.<h4>Patients and methods</h4>Forty-two patients with glioblastoma and 16 patients with anaplastic glioma who had received concurre ...[more]