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Target-selective GABAergic control of entorhinal cortex output.

ABSTRACT: The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We found that cannabinoid type 1 receptor-expressing GABAergic basket cells selectively innervated principal cells in layer II of the rat MEC that projected outside the hippocampus but avoided neighboring cells that give rise to the perforant pathway to the dentate gyrus. These results indicate that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons.

SUBMITTER: Varga C

PROVIDER: S-EPMC3139425 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature

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Target-selective GABAergic control of entorhinal cortex output.

Varga Csaba C Lee Soo Yeun SY Soltesz Ivan I

Nature neuroscience 20100530 7

The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We found that cannabinoid type 1 receptor-expressing GABAergic basket cells selectively innervated principal cells in layer II of the rat MEC that projected outside the hippocampus but avoided neighboring cells that give rise to the perforant pathway to the dentate gyrus. These results indicate that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons. ...[more]

PMID: 20512133

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