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ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.

ABSTRACT: We describe a web tool ENZO (Enzyme Kinetics), a graphical interface for building kinetic models of enzyme catalyzed reactions. ENZO automatically generates the corresponding differential equations from a stipulated enzyme reaction scheme. These differential equations are processed by a numerical solver and a regression algorithm which fits the coefficients of differential equations to experimentally observed time course curves. ENZO allows rapid evaluation of rival reaction schemes and can be used for routine tests in enzyme kinetics. It is freely available as a web tool, at http://enzo.cmm.ki.si.

SUBMITTER: Bevc S

PROVIDER: S-EPMC3139599 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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ENZO: a web tool for derivation and evaluation of kinetic models of enzyme catalyzed reactions.

Bevc Staš S Konc Janez J Stojan Jure J Hodošček Milan M Penca Matej M Praprotnik Matej M Janežič Dušanka D

PloS one 20110719 7

We describe a web tool ENZO (Enzyme Kinetics), a graphical interface for building kinetic models of enzyme catalyzed reactions. ENZO automatically generates the corresponding differential equations from a stipulated enzyme reaction scheme. These differential equations are processed by a numerical solver and a regression algorithm which fits the coefficients of differential equations to experimentally observed time course curves. ENZO allows rapid evaluation of rival reaction schemes and can be u ...[more]

PMID: 21818304

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