Ontology highlight
ABSTRACT:
SUBMITTER: Katsel P
PROVIDER: S-EPMC3139741 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Katsel Pavel P Tan Weilun W Abazyan Bagrat B Davis Kenneth L KL Ross Christopher C Pletnikov Mikhail V MV Haroutunian Vahram V
Schizophrenia research 20110524 1-3
Abnormalities in oligodendrocyte (OLG) differentiation and OLG gene expression deficit have been described in schizophrenia (SZ). Recent studies revealed a critical requirement for Disrupted-in-Schizophrenia 1 (DISC1) in neural development. Transgenic mice with forebrain restricted expression of mutant human DISC1 (ΔhDISC1) are characterized by neuroanatomical and behavioral abnormalities reminiscent of some features of SZ. We sought to determine whether the expression of ΔhDISC1 may influence t ...[more]