Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence.
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ABSTRACT:
SUBMITTER: Contet C
PROVIDER: S-EPMC3139763 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
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Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence.
Contet Candice C Gardon Olivier O Filliol Dominique D Becker Jérôme A J JA Koob George F GF Kieffer Brigitte L BL
Addiction biology 20110311 4
Alcoholism is characterized by a progressive loss of control over ethanol intake. The purpose of this study was to identify transcriptional changes selectively associated with excessive ethanol drinking in dependent mice, as opposed to non-dependent mice maintaining a stable voluntary consumption or mice solely undergoing forced intoxication. We measured expression levels of 106 candidate genes in the extended amygdala, a key brain structure for the development of drug addiction. Cluster analysi ...[more]
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