Dataset Information

Genetic associations with brain microbleeds: Systematic review and meta-analyses.

ABSTRACT:

Objective

We performed a systematic review and meta-analyses to assess the evidence for genetic associations with brain microbleeds (BMBs).

Methods

We sought all published studies of the association between any genetic polymorphism and BMBs studied in a total of >100 people. We critically appraised studies, and calculated pooled odds ratios (ORs) using the generic inverse variance fixed effects method. We used I² and ?² statistics to assess heterogeneity, and fail-safe N estimates to assess the robustness of our results.

Results

Only the APOE ?2/3/4 polymorphism had been studied in >100 people (10 studies, 7,351 participants). Compared with people with the ?3/?3 genotype, carriers of the ?4 allele (?4+) were statistically significantly more likely to have BMBs in any location (?4+ vs ?3/?3: pooled OR 1.22, 95% confidence interval [CI] 1.05-1.41, p = 0.01). For strictly lobar BMBs, this association appeared slightly stronger (?4+ vs ?3/?3: pooled OR 1.35, 95% CI 1.10-1.66, p = 0.005). The association of ?4+ genotypes with strictly lobar BMBs was reasonably robust to potential publication and reporting biases.

Conclusions

Given the known associations of APOE alleles with lobar intracerebral hemorrhage and cerebral amyloid angiopathy, these findings support the concept that strictly lobar BMBs may be an imaging biomarker of cerebral amyloid angiopathy.

SUBMITTER: Maxwell SS

PROVIDER: S-EPMC3140069 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Genetic associations with brain microbleeds: Systematic review and meta-analyses.

Maxwell S S SS Jackson C A CA Paternoster L L Cordonnier C C Thijs V V Al-Shahi Salman R R Sudlow C L M CL

Neurology 20110629 2

<h4>Objective</h4>We performed a systematic review and meta-analyses to assess the evidence for genetic associations with brain microbleeds (BMBs).<h4>Methods</h4>We sought all published studies of the association between any genetic polymorphism and BMBs studied in a total of >100 people. We critically appraised studies, and calculated pooled odds ratios (ORs) using the generic inverse variance fixed effects method. We used I² and χ² statistics to assess heterogeneity, and fail-safe N estimates ...[more]

PMID: 21715706

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Project description:BackgroundNeuroimaging of individuals with non-syndromic oral clefts have revealed subtle brain structural differences compared to matched controls. Previous studies strongly suggest a unified primary dysfunction of normal brain and face development which could explain these neuroanatomical differences and the neuropsychiatric issues frequently observed in these individuals. Currently there are no studies that have assessed the overall empirical evidence of the association between oral clefts and brain structure. Our aim was to summarize the available evidence on potential brain structural differences in individuals with non-syndromic oral clefts and their matched controls.MethodsMEDLINE, Scopus, Cochrane Central Register of Controlled Trials, Web of Science and Embase were systematically searched in September 2020 for case-control studies that reported structural brain MRI in individuals with non-syndromic oral clefts and healthy controls. Studies of syndromic oral clefts were excluded. Two review authors independently screened studies for eligibility, extracted data and assessed risk of bias with the Newcastle-Ottawa Scale. Random effects meta-analyses of mean differences (MDs) and their 95% confidence intervals (95% CI) were performed in order to compare global and regional brain MRI volumes.ResultsTen studies from 18 records were included in the review. A total of 741 participants were analyzed. A moderate to high risk of bias was determined for the included studies. The cerebellum (MD: -12.46 cm3, 95% CI: -18.26, -6.67, n = 3 studies, 354 participants), occipital lobes (MD: -7.39, 95% CI: -12.80, -1.99, n = 2 studies, 120 participants), temporal lobes (MD: -10.53 cm3, 95% CI: -18.23, -2.82, n = 2 studies, 120 participants) and total gray matter (MD: -41.14 cm3; 95% CI: -57.36 to -24.92, n = 2 studies, 172 participants) were significantly smaller in the cleft group compared to controls.DiscussionThere may be structural brain differences between individuals with non-syndromic oral clefts and controls based on the available evidence. Improvement in study design, size, methodology and participant selection could allow a more thorough analysis and decrease study heterogeneity.

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Dataset Information

Genetic associations with brain microbleeds: Systematic review and meta-analyses.

Objective

Methods

Results

Conclusions

Publications

Genetic associations with brain microbleeds: Systematic review and meta-analyses.

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