Ontology highlight
ABSTRACT:
SUBMITTER: Andreola G
PROVIDER: S-EPMC3140222 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Andreola G G Chittenden M M Shaffer J J Cosimi A B AB Kawai T T Cotter P P Locascio S A SA Morokata T T Dey B R BR Tolkoff-Rubin N T NT Preffer F F Bonnefoix T T Kattleman K K Spitzer T R TR Sachs D H DH Sykes M M
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20110601 6
We recently reported long-term organ allograft survival without ongoing immunosuppression in four of five patients receiving combined kidney and bone marrow transplantation from haploidentical donors following nonmyeloablative conditioning. In vitro assays up to 18 months revealed donor-specific unresponsiveness. We now demonstrate that T cell recovery is gradual and is characterized by memory-type cell predominance and an increased proportion of CD4⁺ CD25⁺ CD127⁻ FOXP3⁺ Treg during the lymphope ...[more]