Ontology highlight
ABSTRACT:
SUBMITTER: Muniz VP
PROVIDER: S-EPMC3140613 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Muniz Viviane Palhares VP Barnes J Matthew JM Paliwal Seema S Zhang Xuefeng X Tang Xiaoyun X Chen Songhai S Zamba Kokou D KD Cullen Joseph J JJ Meyerholz David K DK Meyers Shari S Davis J Nathan JN Grossman Steven R SR Henry Michael D MD Quelle Dawn E DE
Molecular cancer research : MCR 20110602 7
Pancreatic ductal adenocarcinoma (PDAC) is an incurable, highly metastatic disease that is largely resistant to existing treatments. A better understanding of the genetic basis of PDAC metastasis should facilitate development of improved therapies. To that end, we developed a novel mouse xenograft model of PDAC metastasis to expedite testing of candidate genes associated with the disease. Human PDAC cell lines BxPC-3, MiaPaCa-2, and Panc-1 stably expressing luciferase were generated and introduc ...[more]