Ontology highlight
ABSTRACT:
SUBMITTER: Hong H
PROVIDER: S-EPMC3140635 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Hong Heedeok H Bowie James U JU
Journal of the American Chemical Society 20110705 29
Membrane proteins have evolved to fold and function in a lipid bilayer, so it is generally assumed that their stability should be optimized in a natural membrane environment. Yet optimal stability is not always in accord with optimization of function, so evolutionary pressure, occurring in a complex membrane environment, may favor marginal stability. Here, we find that the transmembrane helix dimer, glycophorin A (GpATM), is actually much less stable in the heterogeneous environment of a natural ...[more]