Ontology highlight
ABSTRACT:
SUBMITTER: Goicochea NL
PROVIDER: S-EPMC3140650 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Goicochea Nancy L NL Datta Siddhartha A K SA Ayaluru Murali M Kao Cheng C Rein Alan A Dragnea Bogdan B
Journal of molecular biology 20110701 4
Size polydispersity of immature human immunodeficiency virus type 1 (HIV-1) particles represents a challenge for traditional methods of biological ultrastructural analysis. An in vitro model for immature HIV-1 particles constructed from recombinant Gag proteins lacking residues 16-99 and the p6 domain assembled around spherical nanoparticles functionalized with DNA. This template-directed assembly approach led to a significant reduction in size polydispersity and revealed previously unknown stru ...[more]