Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.

ABSTRACT: Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(-8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined)?=?2.3×10(-10), odds ratio [OR]?=?1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P?=?5.5×10(-10), OR?=?1.52, and DPB1*0901: P?=?2.0×10(-7), OR?=?1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations.

SUBMITTER: Noguchi E 

PROVIDER: S-EPMC3140987 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature