Ontology highlight
ABSTRACT:
SUBMITTER: Szatanik M
PROVIDER: S-EPMC3141004 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Szatanik Marek M Hong Eva E Ruckly Corinne C Ledroit Morgan M Giorgini Dario D Jopek Katarzyna K Nicola Marie-Anne MA Deghmane Ala-Eddine AE Taha Muhamed-Kheir MK
PloS one 20110721 7
Severe meningococcal sepsis is still of high morbidity and mortality. Its management may be improved by an experimental model allowing better understanding of its pathophysiology. We developed an animal model of meningococcal sepsis in transgenic BALB/c mice expressing human transferrin. We studied experimental meningococcal sepsis in congenic transgenic BALB/c mice expressing human transferrin by transcriptional profiling using microarray analysis of blood and brain samples. Genes encoding acut ...[more]