Ontology highlight
ABSTRACT:
SUBMITTER: Benatti P
PROVIDER: S-EPMC3141247 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Benatti Paolo P Dolfini Diletta D Viganò Alessandra A Ravo Maria M Weisz Alessandro A Imbriano Carol C
Nucleic acids research 20110316 13
Regulated gene expression is essential for a proper progression through the cell cycle. The transcription factor NF-Y has a fundamental function in transcriptional regulation of cell cycle genes, particularly of G2/M genes. In order to investigate common and distinct functions of NF-Y subunits in cell cycle regulation, NF-YA, NF-YB and NF-YC have been silenced by shRNAs in HCT116 cells. NF-YA loss led to a delay in S-phase progression, DNA damage and apoptosis: we showed the activation of the re ...[more]