Ontology highlight
ABSTRACT:
SUBMITTER: Vassilenko KS
PROVIDER: S-EPMC3141257 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Vassilenko Konstantin S KS Alekhina Olga M OM Dmitriev Sergey E SE Shatsky Ivan N IN Spirin Alexander S AS
Nucleic acids research 20110316 13
According to the model of translation initiation in eukaryotes, the 40S ribosomal subunit binds to capped 5'-end of mRNA and subsequently migrates along 5'-UTR in searching for initiation codon. However, it remains unclear whether the migration is the result of a random one-dimensional diffusion, or it is an energy-driven unidirectional movement. To address this issue, the method of continuous monitoring of protein synthesis in situ was used for high precision measurements of the times required ...[more]