Ontology highlight
ABSTRACT:
SUBMITTER: Hansel R
PROVIDER: S-EPMC3141269 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Nucleic acids research 20110330 13
G-quadruplex topologies of telomeric repeat sequences from vertebrates were investigated in the presence of molecular crowding (MC) mimetics, namely polyethylene glycol 200 (PEG), Ficoll 70 as well as Xenopus laevis egg extract by CD and NMR spectroscopy and native PAGE. Here, we show that the conformational behavior of the telomeric repeats in X. laevis egg extract or in Ficoll is notably different from that observed in the presence of PEG. While the behavior of the telomeric repeat in X. laevi ...[more]