Ontology highlight
ABSTRACT:
SUBMITTER: Marsh-Armstrong N
PROVIDER: S-EPMC314156 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Marsh-Armstrong Nicholas N Cai Liquan L Brown Donald D DD
Proceedings of the National Academy of Sciences of the United States of America 20031222 1
During premetamorphic stages, Xenopus laevis tadpoles expressing either a dominant-negative thyroid hormone (TH) receptor or a type-III iodothyronine deiodinase transgene in the nervous system have reduced TH-induced proliferation in the spinal cord and produce fewer hindlimb-innervating motorneurons. During prometamorphic stages, innervation of the hindlimbs is reduced, and few functional neuromuscular connections are formed. By metamorphic climax, limb movement is impaired, ranging from uncoor ...[more]