Motor training compensates for cerebellar dysfunctions caused by oligodendrocyte ablation.
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ABSTRACT:
SUBMITTER: Collin L
PROVIDER: S-EPMC314184 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
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Motor training compensates for cerebellar dysfunctions caused by oligodendrocyte ablation.
Collin Ludovic L Usiello Alessandro A Erbs Eric E Mathis Carole C Borrelli Emiliana E
Proceedings of the National Academy of Sciences of the United States of America 20031223 1
The role played by oligodendrocytes (OLs), the myelinating cells of the CNS, during brain development has not been fully explored. We have addressed this question by inducing a temporal and reversible ablation of OLs on postnatal CNS development. OL ablation in newborn mice leads to a profound alteration in the structure of the cerebellar cortex, which can be progressively rescued by newly generated cells, leading to a delayed myelination. Nevertheless, the temporal shift of the OL proliferation ...[more]
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