Ontology highlight
ABSTRACT:
SUBMITTER: Halim A
PROVIDER: S-EPMC3141957 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Halim Adnan A Brinkmalm Gunnar G Brinkmalm Gunnar G Rüetschi Ulla U Westman-Brinkmalm Ann A Portelius Erik E Zetterberg Henrik H Blennow Kaj K Larson Göran G Nilsson Jonas J
Proceedings of the National Academy of Sciences of the United States of America 20110628 29
The proteolytic processing of human amyloid precursor protein (APP) into shorter aggregating amyloid β (Aβ)-peptides, e.g., Aβ1-42, is considered a critical step in the pathogenesis of Alzheimer's disease (AD). Although APP is a well-known membrane glycoprotein carrying both N- and O-glycans, nothing is known about the occurrence of released APP/Aβ glycopeptides in cerebrospinal fluid (CSF). We used the 6E10 antibody and immunopurified Aβ peptides and glycopeptides from CSF samples and then liqu ...[more]