Dataset Information

Low free testosterone levels are associated with all-cause and cardiovascular mortality in postmenopausal diabetic women.

ABSTRACT:

Objective

Hyperandrogenemia is associated with cardiovascular risk factors in women but evidence about the relationship of testosterone levels with mortality is sparse. We aimed to evaluate whether total testosterone (TT), free testosterone (FT), and sex hormone-binding globulin (SHBG) are associated with all-cause and cardiovascular mortality in a cohort of postmenopausal women.

Research design and methods

We measured TT and SHBG levels in 875 postmenopausal women who were referred for coronary angiography (during 1997-2000). FT was calculated according to the Vermeulen method. The main outcome measures were Cox proportional hazard ratios (HRs) for mortality from all causes and from cardiovascular causes.

Results

After a median follow-up time of 7.7 years, 179 women (20.5%) had died. There were 101 deaths due to cardiovascular disease (56.4% of all deaths). We found no association of FT, TT, and SHBG levels with mortality in all postmenopausal women. In postmenopausal diabetic women, multivariable-adjusted HRs (with 95% CIs) in the fourth compared with the first FT quartile for all-cause and cardiovascular mortality were 0.38 (0.08-0.90), P = 0.025, and 0.28 (0.08-0.90), P = 0.032, respectively. We found no association of TT and SHBG with mortality in diabetic postmenopausal women.

Conclusions

In postmenopausal diabetic women referred for coronary angiography, low FT levels are independently associated with increased all-cause and cardiovascular mortality.

SUBMITTER: Wehr E

PROVIDER: S-EPMC3142041 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Low free testosterone levels are associated with all-cause and cardiovascular mortality in postmenopausal diabetic women.

Wehr Elisabeth E Pilz Stefan S Boehm Bernhard O BO Grammer Tanja B TB März Winfried W Obermayer-Pietsch Barbara B

Diabetes care 20110629 8

<h4>Objective</h4>Hyperandrogenemia is associated with cardiovascular risk factors in women but evidence about the relationship of testosterone levels with mortality is sparse. We aimed to evaluate whether total testosterone (TT), free testosterone (FT), and sex hormone-binding globulin (SHBG) are associated with all-cause and cardiovascular mortality in a cohort of postmenopausal women.<h4>Research design and methods</h4>We measured TT and SHBG levels in 875 postmenopausal women who were referr ...[more]

PMID: 21715525

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Dataset Information

Low free testosterone levels are associated with all-cause and cardiovascular mortality in postmenopausal diabetic women.

Objective

Research design and methods

Results

Conclusions

Publications

Low free testosterone levels are associated with all-cause and cardiovascular mortality in postmenopausal diabetic women.

Similar Datasets

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