Dataset Information

Biomarkers of renal function and cognitive impairment in patients with diabetes.

ABSTRACT:

Objective

Kidney disease is associated with cognitive impairment in studies of nondiabetic adults. We examined the cross-sectional relation between three measures of renal function and performance on four measures of cognitive function in the Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD-MIND) study.

Research design and methods

The relationships among estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) (n = 2,968), albumin/creatinine ratio (ACR) ?30 ?g/mg (n = 2,957), and cystatin C level >1.0 mg/L (n = 532) with tertile of performance on the Mini-Mental State Examination, Rey Auditory Verbal Learning Test (RAVLT), Digit Symbol Substitution Test (DSST), and Stroop Test of executive function were measured.

Results

In adjusted logistic regression models, ACR ?30 ?g/mg was associated with performance in the lowest tertile, compared with the highest two tertiles, on the RAVLT (odds ratio 1.30, 95% CI 1.09-1.56, P = 0.006), equivalent to 3.6 years of aging, and on the DSST (1.47, 1.20-1.80, P = 0.001), equivalent to 3.7 years of aging. Cystatin C >1.0 mg/L was borderline associated with the lowest tertile on the DSST (1.81, 0.93-3.55, P = 0.08) and Stroop (1.78, 0.97-3.23, P = 0.06) in adjusted models. eGFR was not associated with any measure of cognitive performance.

Conclusions

In diabetic people with HbA(1c) >7.5% at high risk for cardiovascular disease, decreased cognitive function was associated with kidney disease as measured by ACR, a measure of microvascular endothelial pathology, and cystatin C, a marker of eGFR.

SUBMITTER: Murray AM

PROVIDER: S-EPMC3142061 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Publications

Biomarkers of renal function and cognitive impairment in patients with diabetes.

Murray Anne M AM Barzilay Joshua I JI Lovato James F JF Williamson Jeff D JD Miller Michael E ME Marcovina Santica S Launer Lenore J LJ

Diabetes care 20110629 8

<h4>Objective</h4>Kidney disease is associated with cognitive impairment in studies of nondiabetic adults. We examined the cross-sectional relation between three measures of renal function and performance on four measures of cognitive function in the Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes (ACCORD-MIND) study.<h4>Research design and methods</h4>The relationships among estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) (n = 2,968), albumin/creatinine rat ...[more]

PMID: 21715519

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Dataset Information

Biomarkers of renal function and cognitive impairment in patients with diabetes.

Objective

Research design and methods

Results

Conclusions

Publications

Biomarkers of renal function and cognitive impairment in patients with diabetes.

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