Evaluating the effects of genetic variants of DNA repair genes using cytogenetic mutagen sensitivity approaches.
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ABSTRACT:
SUBMITTER: Abdel-Rahman SZ
PROVIDER: S-EPMC3142279 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
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Evaluating the effects of genetic variants of DNA repair genes using cytogenetic mutagen sensitivity approaches.
Abdel-Rahman Sherif Z SZ El-Zein Randa A RA
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20110520 5
Mutagen sensitivity, measured in short-term cultures of peripheral blood lymphocytes by cytogenetic endpoints, is an indirect measure for DNA repair capacity and has been used for many years as a biomarker for intrinsic susceptibility for cancer. In this article, we briefly give an overview of the different cytogenetic mutagen sensitivity approaches that have been used successfully to evaluate the biological effects of polymorphisms in DNA repair genes based on a current review of the literature ...[more]
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