Sam68 is required for both NF-?B activation and apoptosis signaling by the TNF receptor.
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ABSTRACT:
SUBMITTER: Ramakrishnan P
PROVIDER: S-EPMC3142289 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
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Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor.
Ramakrishnan Parameswaran P Baltimore David D
Molecular cell 20110527 2
The RNA-binding protein Sam68 is implicated in various cellular processes including RNA metabolism, apoptosis, and signal transduction. Here we identify a role of Sam68 in TNF-induced NF-κB activation and apoptosis. We found that Sam68 is recruited to the TNF receptor, and its deficiency dramatically reduces RIP recruitment and ubiquitylation. It also impairs cIAP1 recruitment and maintenance of recruited TRAF2 at the TNF receptor. In its absence, activation of the TAK1-IKK kinase complex is def ...[more]
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