Ontology highlight
ABSTRACT:
SUBMITTER: Wilson DS
PROVIDER: S-EPMC3142359 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Wilson D Scott DS Dalmasso Guillaume G Wang Lixin L Sitaraman Shanthi V SV Merlin Didier D Murthy Niren N
Nature materials 20101010 11
Small interfering RNAs (siRNAs) directed against proinflammatory cytokines have the potential to treat numerous diseases associated with intestinal inflammation; however, the side-effects caused by the systemic depletion of cytokines demands that the delivery of cytokine-targeted siRNAs be localized to diseased intestinal tissues. Although various delivery vehicles have been developed to orally deliver therapeutics to intestinal tissue, none of these strategies has demonstrated the ability to pr ...[more]