The landscape of C. elegans 3'UTRs.
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ABSTRACT:
SUBMITTER: Mangone M
PROVIDER: S-EPMC3142571 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
The landscape of C. elegans 3'UTRs.
Mangone Marco M Manoharan Arun Prasad AP Thierry-Mieg Danielle D Thierry-Mieg Jean J Han Ting T Mackowiak Sebastian D SD Mis Emily E Zegar Charles C Gutwein Michelle R MR Khivansara Vishal V Attie Oliver O Chen Kevin K Salehi-Ashtiani Kourosh K Vidal Marc M Harkins Timothy T TT Bouffard Pascal P Suzuki Yutaka Y Sugano Sumio S Kohara Yuji Y Rajewsky Nikolaus N Piano Fabio F Gunsalus Kristin C KC Kim John K JK
Science (New York, N.Y.) 20100603 5990
Three-prime untranslated regions (3'UTRs) of metazoan messenger RNAs (mRNAs) contain numerous regulatory elements, yet remain largely uncharacterized. Using polyA capture, 3' rapid amplification of complementary DNA (cDNA) ends, full-length cDNAs, and RNA-seq, we defined approximately 26,000 distinct 3'UTRs in Caenorhabditis elegans for approximately 85% of the 18,328 experimentally supported protein-coding genes and revised approximately 40% of gene models. Alternative 3'UTR isoforms are freque ...[more]
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