Impact of dietary calcium and oxalate, and Oxalobacter formigenes colonization on urinary oxalate excretion.

ABSTRACT:

Purpose

Enteric colonization with Oxalobacter formigenes, a bacterium whose main energy source is oxalate, has been demonstrated to decrease the risk of recurrent calcium oxalate kidney stone formation. We assessed the impact of diets controlled in calcium and oxalate contents on urinary and fecal analytes in healthy subjects who were naturally colonized with O. formigenes or not colonized with O. formigenes.

Materials and methods

A total of 11 O. formigenes colonized and 11 noncolonized subjects were administered diets controlled in calcium and oxalate contents. We assayed 24-hour urine collections and stool samples obtained on the last 4 days of each 1-week diet for stone risk parameters and O. formigenes levels. Mixed model analysis was used to determine the effects of co

SUBMITTER: Jiang J 

PROVIDER: S-EPMC3143112 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature