Ontology highlight
ABSTRACT:
SUBMITTER: Bonsor DA
PROVIDER: S-EPMC3143254 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Journal of molecular biology 20110612 2
Protein engineering is becoming increasingly important for pharmaceutical applications where controlling the specificity and affinity of engineered proteins is required to create targeted protein therapeutics. Affinity increases of several thousand-fold are now routine for a variety of protein engineering approaches, and the structural and energetic bases of affinity maturation have been investigated in a number of such cases. Previously, a 3-million-fold affinity maturation process was achieved ...[more]