Ontology highlight
ABSTRACT:
SUBMITTER: Nair U
PROVIDER: S-EPMC3143362 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Nair Usha U Jotwani Anjali A Geng Jiefei J Gammoh Noor N Richerson Diana D Yen Wei-Lien WL Griffith Janice J Nag Shanta S Wang Ke K Moss Tyler T Baba Misuzu M McNew James A JA Jiang Xuejun X Reggiori Fulvio F Melia Thomas J TJ Klionsky Daniel J DJ
Cell 20110701 2
Macroautophagy mediates the degradation of long-lived proteins and organelles via the de novo formation of double-membrane autophagosomes that sequester cytoplasm and deliver it to the vacuole/lysosome; however, relatively little is known about autophagosome biogenesis. Atg8, a phosphatidylethanolamine-conjugated protein, was previously proposed to function in autophagosome membrane expansion, based on the observation that it mediates liposome tethering and hemifusion in vitro. We show here that ...[more]