Hypoxia-inducible factors and the response to hypoxic stress.
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ABSTRACT:
SUBMITTER: Majmundar AJ
PROVIDER: S-EPMC3143508 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
Hypoxia-inducible factors and the response to hypoxic stress.
Majmundar Amar J AJ Wong Waihay J WJ Simon M Celeste MC
Molecular cell 20101001 2
Oxygen (O(2)) is an essential nutrient that serves as a key substrate in cellular metabolism and bioenergetics. In a variety of physiological and pathological states, organisms encounter insufficient O(2) availability, or hypoxia. In order to cope with this stress, evolutionarily conserved responses are engaged. In mammals, the primary transcriptional response to hypoxic stress is mediated by the hypoxia-inducible factors (HIFs). While canonically regulated by prolyl hydroxylase domain-containin ...[more]
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