Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis.
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SUBMITTER: Tanaka M
PROVIDER: S-EPMC314355 | biostudies-literature | 2000 Jul
REPOSITORIES: biostudies-literature
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Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis.
Tanaka M M Kishimura M M Ozaki S S Osakada F F Hashimoto H H Okubo M M Murakami M M Nakao K K
The Journal of clinical investigation 20000701 1
In an attempt to isolate disease-associated autoantigens in rheumatoid arthritis (RA), we cloned a new autoantigen named gp130-RAPS, which is a novel soluble form of the IL-6 signal-transducing molecule gp130. gp130-RAPS is a 50-kDa protein translated from alternatively spliced mRNA and has a truncated form of gp130 with a unique sequence, Asn-Ile-Ala-Ser-Phe (NIASF), in its COOH-terminus. We observed serum antibodies to this NIASF sequence frequently in patients with RA, but not in those with o ...[more]
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