TNF-alpha promotes an odontoblastic phenotype in dental pulp cells.
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ABSTRACT:
SUBMITTER: Paula-Silva FW
PROVIDER: S-EPMC3144054 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
TNF-alpha promotes an odontoblastic phenotype in dental pulp cells.
Paula-Silva F W G FW Ghosh A A Silva L A B LA Kapila Y L YL
Journal of dental research 20090401 4
Dental pulp cells can differentiate toward an odontoblastic phenotype to produce reparative dentin beneath caries lesions. However, the mechanisms involved in pulp cell differentiation under pro-inflammatory stimuli have not been well-explored. Thus, we hypothesized that the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) could be a mediator involved in dental pulp cell differentiation toward an odontoblastic phenotype. We observed that TNF-alpha-challenged pulp cells exhibited ...[more]
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