Ontology highlight
ABSTRACT:
SUBMITTER: Agua-Doce A
PROVIDER: S-EPMC3144234 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
PloS one 20110726 7
Allergic airways disease is a consequence of a Th2 response to an allergen leading to a series of manifestations such as production of allergen-specific IgE, inflammatory infiltrates in the airways, and airway hyper-reactivity (AHR). Several strategies have been reported for tolerance induction to allergens leading to protection from allergic airways disease. We now show that CD4 blockade at the time of house dust mite sensitization induces antigen-specific tolerance in mice. Tolerance induction ...[more]