Ontology highlight
ABSTRACT:
SUBMITTER: Miyata Y
PROVIDER: S-EPMC3144254 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Miyata Yasuhiko Y Liu Yan Y Jankovic Vladimir V Sashida Goro G Lee Jennifer May JM Shieh Jae-Hung JH Naoe Tomoki T Moore Malcolm M Nimer Stephen D SD
Stem cells (Dayton, Ohio) 20100201 2
Hematopoietic stem cells (HSCs) can remain quiescent or they can enter the cell cycle, and either self-renew or differentiate. Although cyclin C and cyclin dependent kinase (cdk3) are essential for the transition from the G(0) to the G(1) phase of the cell cycle in human fibroblasts, the role of cyclin C in hematopoietic stem/progenitor cells (HSPCs) is not clear. We have identified an important role of cyclin C (CCNC) in regulating human HSPC quiescence, as knocking down CCNC expression in huma ...[more]