Ontology highlight
ABSTRACT:
SUBMITTER: Eyler CE
PROVIDER: S-EPMC3144745 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Eyler Christine E CE Wu Qiulian Q Yan Kenneth K MacSwords Jennifer M JM Chandler-Militello Devin D Misuraca Katherine L KL Lathia Justin D JD Forrester Michael T MT Lee Jeongwu J Stamler Jonathan S JS Goldman Steven A SA Bredel Markus M McLendon Roger E RE Sloan Andrew E AE Hjelmeland Anita B AB Rich Jeremy N JN
Cell 20110701 1
Malignant gliomas are aggressive brain tumors with limited therapeutic options, and improvements in treatment require a deeper molecular understanding of this disease. As in other cancers, recent studies have identified highly tumorigenic subpopulations within malignant gliomas, known generally as cancer stem cells. Here, we demonstrate that glioma stem cells (GSCs) produce nitric oxide via elevated nitric oxide synthase-2 (NOS2) expression. GSCs depend on NOS2 activity for growth and tumorigeni ...[more]