Ontology highlight
ABSTRACT:
SUBMITTER: Cea M
PROVIDER: S-EPMC3144930 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Cea Michele M Soncini Debora D Fruscione Floriana F Raffaghello Lizzia L Garuti Anna A Emionite Laura L Moran Eva E Magnone Mirko M Zoppoli Gabriele G Reverberi Daniele D Caffa Irene I Salis Annalisa A Cagnetta Antonia A Bergamaschi Micaela M Casciaro Salvatore S Pierri Ivana I Damonte Gianluca G Ansaldi Filippo F Gobbi Marco M Pistoia Vito V Ballestrero Alberto A Patrone Franco F Bruzzone Santina S Nencioni Alessio A
PloS one 20110727 7
Aberrant histone deacetylase (HDAC) activity is frequent in human leukemias. However, while classical, NAD(+)-independent HDACs are an established therapeutic target, the relevance of NAD(+)-dependent HDACs (sirtuins) in leukemia treatment remains unclear. Here, we assessed the antileukemic activity of sirtuin inhibitors and of the NAD(+)-lowering drug FK866, alone and in combination with traditional HDAC inhibitors. Primary leukemia cells, leukemia cell lines, healthy leukocytes and hematopoiet ...[more]