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Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing.

ABSTRACT: The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. On the basis of whole-genome sequences of 69 females, we report that whereas this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection.

SUBMITTER: Gottipati S

PROVIDER: S-EPMC3145052 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing.

Gottipati Srikanth S Arbiza Leonardo L Siepel Adam A Clark Andrew G AG Keinan Alon A

Nature genetics 20110724 8

The ratio of genetic diversity on chromosome X to that on the autosomes is sensitive to both natural selection and demography. On the basis of whole-genome sequences of 69 females, we report that whereas this ratio increases with genetic distance from genes across populations, it is lower in Europeans than in West Africans independent of proximity to genes. This relative reduction is most parsimoniously explained by differences in demographic history without the need to invoke natural selection. ...[more]

PMID: 21775991

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