Interactions of cations with RNA loop-loop complexes.
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ABSTRACT:
SUBMITTER: Singh A
PROVIDER: S-EPMC3145274 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Interactions of cations with RNA loop-loop complexes.
Singh Abhishek A Sethaphong Latsavongsakda L Yingling Yaroslava G YG
Biophysical journal 20110801 3
RNA loop-loop interactions are essential in many biological processes, including initiation of RNA folding into complex tertiary shapes, promotion of dimerization, and viral replication. In this article, we examine interactions of metal ions with five RNA loop-loop complexes of unique biological significance using explicit-solvent molecular-dynamics simulations. These simulations revealed the presence of solvent-accessible tunnels through the major groove of loop-loop interactions that attract a ...[more]
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