Ontology highlight
ABSTRACT:
SUBMITTER: Ibrahim SH
PROVIDER: S-EPMC3145329 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Ibrahim Samar H SH Kohli Rohit R Gores Gregory J GJ
Journal of pediatric gastroenterology and nutrition 20110801 2
With the epidemic of childhood obesity, nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease in pediatrics. NAFLD is strongly associated with insulin resistance and increased level of serum free fatty acids (FFAs). FFAs have direct hepatotoxicity through the induction of an endoplasmic reticulum stress response and subsequently activation of the mitochondrial pathway of cell death. FFAs may also result in lysosomal dysfunction and alter death recepto ...[more]