Ontology highlight
ABSTRACT:
SUBMITTER: Gordan JD
PROVIDER: S-EPMC3145406 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Gordan John D JD Bertout Jessica A JA Hu Cheng-Jun CJ Diehl J Alan JA Simon M Celeste MC
Cancer cell 20070401 4
HIF-2alpha promotes von Hippel-Lindau (VHL)-deficient renal clear cell carcinoma (RCC) tumorigenesis, while HIF-1alpha inhibits RCC growth. As HIF-1alpha antagonizes c-Myc function, we hypothesized that HIF-2alpha might enhance c-Myc activity. We demonstrate here that HIF-2alpha promotes cell-cycle progression in hypoxic RCCs and multiple other cell lines. This correlates with enhanced c-Myc promoter binding, transcriptional effects on both activated and repressed target genes, and interactions ...[more]