Routine invasive management after fibrinolysis in patients with ST-elevation myocardial infarction: a systematic review of randomized clinical trials.

ABSTRACT:

Background

Patients with ST-elevation myocardial infarction (STEMI) treated with fibrinolysis are increasingly, and ever earlier, referred for routine coronary angiography and where feasible, undergo percutaneous coronary intervention (PCI). We sought to examine the randomized clinical trials (RCTs) on which this approach is based.

Methods

We systematically searched EMBASE, Medline, and references of relevant studies. All contemporary RCTs (published since 1995) that compared systematic invasive management of STEMI patients after fibrinolysis with standard care were included. Relevant study design and clinical outcome data were extracted.

Results

Nine RCTs that randomized a total of 3320 patients were identified. All suggested a benefit from routine early invasive man

SUBMITTER: Bogaty P 

PROVIDER: S-EPMC3145591 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature