Ontology highlight
ABSTRACT:
SUBMITTER: Silva RF
PROVIDER: S-EPMC3145620 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Silva Rui F RF Mendonça Sílvia C M SC Carvalho Luís M LM Reis Ana M AM Gordo Isabel I Trindade Sandra S Dionisio Francisco F
PLoS genetics 20110728 7
Multidrug-resistant bacteria arise mostly by the accumulation of plasmids and chromosomal mutations. Typically, these resistant determinants are costly to the bacterial cell. Yet, recently, it has been found that, in Escherichia coli bacterial cells, a mutation conferring resistance to an antibiotic can be advantageous to the bacterial cell if another antibiotic-resistance mutation is already present, a phenomenon called sign epistasis. Here we study the interaction between antibiotic-resistance ...[more]