?-Adrenergic inhibition of contractility in L6 skeletal muscle cells.
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ABSTRACT:
SUBMITTER: Oberg AI
PROVIDER: S-EPMC3145637 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
β-Adrenergic inhibition of contractility in L6 skeletal muscle cells.
Öberg Anette I AI Dehvari Nodi N Bengtsson Tore T
PloS one 20110728 7
The β-adrenoceptors (β-ARs) control many cellular processes. Here, we show that β-ARs inhibit calcium depletion-induced cell contractility and subsequent cell detachment of L6 skeletal muscle cells. The mechanism underlying the cell detachment inhibition was studied by using a quantitative cell detachment assay. We demonstrate that cell detachment induced by depletion of extracellular calcium is due to myosin- and ROCK-dependent contractility. The β-AR inhibition of L6 skeletal muscle cell detac ...[more]
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