Ontology highlight
ABSTRACT:
SUBMITTER: Selesniemi K
PROVIDER: S-EPMC3145697 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Selesniemi Kaisa K Lee Ho-Joon HJ Muhlhauser Ailene A Tilly Jonathan L JL
Proceedings of the National Academy of Sciences of the United States of America 20110705 30
Increased meiotic spindle abnormalities and aneuploidy in oocytes of women of advanced maternal ages lead to elevated rates of infertility, miscarriage, and trisomic conceptions. Despite the significance of the problem, strategies to sustain oocyte quality with age have remained elusive. Here we report that adult female mice maintained under 40% caloric restriction (CR) did not exhibit aging-related increases in oocyte aneuploidy, chromosomal misalignment on the metaphase plate, meiotic spindle ...[more]